New
Positive Data From VYNE Therapeutics
VYNE Therapeutics Inc. recently announced positive results from the Phase 1a portion of its Phase 1a/b clinical trial evaluating its novel BET inhibitor, VYN201, for vitiligo.
This drug candidate is a locally administered, small molecule, pan-bromodomain and extra-terminal domain (BET) inhibitor. VYN201 was found to upregulate the WNT signaling pathway which is an important mediator of both melanogenesis and melanocyte differentiation and is known to be dysregulated in patients with vitiligo. Library of BET inhibitors is licensed from Tay Therapeutics Ltd, and protected by a GB patent titled 'Compounds Comprising N-Methyl-2-Pyridone, And Pharmaceutically Acceptable Salts.'
30 healthy volunteers were given single and multiple ascending doses of VYN201 ointment in five dose cohorts over two weeks, with a one-week safety follow-up visit. The doses included 0.025%, 0.1%, 0.5%, 1.0% and 2.0%, and it was generally well-tolerated with no clinically relevant adverse events from all dose cohorts.
In addition to the safety assessment, exploratory efficacy of VYN201 in non-segmental vitiligo patients will be evaluated, including pharmacodynamic biomarkers and photography.
These positive results have also caused VYNE Therapeutics shares to increase 8%.
📌 Vitiligo Drug Pipeline Analysis and Market Insights
FAQOther Questions
- Is there a link between vitiligo and depression?
Depression and anxiety are often linked with vitiligo, significantly impacting a person’s quality of life. The connection stems from the shared origin of the skin and brain duri...
- Is there a traditional medicine to treat vitiligo?
Traditional remedies can be helpful for managing stress or general metabolic health, but when it comes to vitiligo, the evidence is limited. While some natural supplements provi...
- I have a new job - should I tell colleagues about my vitiligo?
Starting a new job can be both exciting and nerve-wracking, — especially if you’re concerned about stares or questions regarding your skin. Taking a proactive approach can help ...
Though it is not always easy to treat vitiligo, there is much to be gained by clearly understanding the diagnosis, the future implications, treatment options and their outcomes.
Many people deal with vitiligo while remaining in the public eye, maintaining a positive outlook, and having a successful career.
Copyright (C) Bodolóczki JúliaBy taking a little time to fill in the anonymous questionnaire, you can help researchers better understand and fight vitiligo.