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Publication
Glabrous lesional stem cells differentiated into functional melanocytes: new hope for regimentation
This study is designed to check the glabrous lesional skin for the presence of stem cells as source of melanocytes for repigmentation. Our results demonstrate that NGFRp75-positive stem cells are present in the glabrous lesional skin of vitiligo patients and can be differentiated into melanocytes. These dermal stem cells showed self-renewal capacity and were capable of differentiating into melanocytes which are required for the repigmentation. Presence of stem cells in the glabrous lesional skin which are capable of self-renewal and differentiating into melanocytes gives new hope for vitiligo patients having lesion on the glabrous skin. However, still repigmentation of glabrous lesional skin is very difficult and rare with current available treatments. This clearly means that treatments available till date are not effective enough to activate these dermal stem cells differentiation and their migration to the lesional epidermis. Stimulating these stem cells to differentiate into melanocytes and migrate to lesional epidermis can be ideal for repigmentation of the glabrous lesions.
R. Kumar, D. Parsad, S. Rani, S. Bhardwaj, N. Srivastav
FAQOther Questions
- Is there a special diet for vitiligo?
Recent research highlights the potential of diet and nutrition in managing vitiligo, offering an alternative where traditional therapies may be lacking. However, the relationshi...
- Isn't it just a cosmetic disorder?
Contrary to popular belief, vitiligo is not merely a cosmetic issue but a complex autoimmune disorder that affects the body’s largest organ—along with other vital systems—and is...
- Do Antioxidant Supplements Help Vitiligo?
Do Antioxidant Supplements Help Vitiligo? Short answer Maybe a little. But probably not in the way most people hope. Antioxidant supplements may offer modest support, especially...
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