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Treatment guideline
While vitiligo is an incurable condition, it is manageable through various treatment options. These include FDA-approved and off-label medications, light therapy, microsurgery, and adjunctive therapies. The effectiveness of these treatments varies based on factors such as the patient's age, time since disease onset, skin phototype, genetic background, and other considerations.
Leading the drug treatments are advanced JAK inhibitors like Opzelura® from biotech firm Incyte, and Litfulo® from pharmaceutical giant Pfizer, in the last phase of clinical trials. These drugs act as immune system regulators, targeting specific communication pathways to control irregular immune responses.
Opzelura® (1.5% ruxolitinib), notably the first FDA-approved drug for vitiligo, is a topical treatment suitable for individuals aged 12 and above. Recommended usage involves twice-daily application to affected areas, especially on the face, with no fixed limit on duration of use, provided there are visible improvements. Results vary; some may see benefits within 24 weeks, while others might need up to a year. Dermatologists often prioritize its use on the face and sensitive areas like the genitals, areola, or ventral breast. Research suggests that low-level light exposure may enhance the drug's effectiveness, although the drug alone can maintain repigmentation.
The drug development pipeline for vitiligo treatments is promising. Currently, a dozen pharmaceutical and biotech companies are actively investing in vitiligo research and development programs. This ongoing research holds the potential for new and more effective treatments in the future.
FAQOther Questions
- Which skin conditions can be mistaken for vitiligo?
Vitiligo is a common skin condition with characteristic milky white patches of irregular shape. However, several other skin conditions exhibit similar symptoms that can lead to ...
- Isn't it just a cosmetic disorder?
Contrary to popular belief, vitiligo is not merely a cosmetic issue but a complex autoimmune disorder that affects the body’s largest organ—along with other vital systems—and is...
- What causes vitiligo?
Surprisingly, the causes of vitiligo are yet to be precisely established. Researchers know the cause is pre-wired in your genes, just waiting for a bad luck moment. In about hal...
Though it is not always easy to treat vitiligo, there is much to be gained by clearly understanding the diagnosis, the future implications, treatment options and their outcomes.
Many people deal with vitiligo while remaining in the public eye, maintaining a positive outlook, and having a successful career.
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