229 listed sites: Australia (11); Belgium (5); Bulgaria (14); Canada (23); China (22); Germany (12); Hungary (8); Italy (7); Japan (10); Mexico (5); Poland (11); Puerto Rico (3); Slovakia (8); Spain (12); Taiwan (5); Turkey (Türkiye) (2); United Kingdom (3); United States (68) - 08 Nov `23Ritlecitinib for nonsegmental vitiligo

Ritlecitinib for nonsegmental vitiligo

Official title: A PHASE 3 RANDOMIZED, DOUBLE-BLIND, 52-WEEK PLACEBO-CONTROLLED MULTI-CENTER STUDY WITH A DOUBLE-BLIND 52-WEEK EXTENSION PERIOD WITH RANDOMIZED DOSE UP/DOSE DOWN TITRATION INVESTIGATING THE EFFICACY, SAFETY, AND TOLERABILITY OF RITLECITINIB IN ADULT PARTICIPANTS WITH NONSEGMENTAL VITILIGO

Status: Closed to new participants

Description:

Pfizer enrolled about 1,571 participants. Ritlecitinib is an oral immune-modulating drug that blocks JAK3 and TEC-family signaling. Researchers hope it will reduce the immune attack on melanocytes and support repigmentation. Ritlecitinib is sold as Litfulo and is approved for severe alopecia areata in people age 12 and older; vitiligo would be a new use. Possible effects include headache, diarrhea, acne, and infections. People age 18 and older may qualify. The study is underway but is no longer accepting new participants.

Start date: November 08, 2023

Completion date: July 30, 2027

Organizer: Pfizer

Contact: Pfizer CT.gov Call Center

Link: https://clinicaltrials.gov/study/NCT06072183

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