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The Value of Adding Mini-oral Pulse Steroid Therapy in Preventing Peri-lesional Halo Post Non-cultured Epidermal Cell Suspension (NCES) in Cases With Stable Segmental and Non-acral Vitiligo.
Official title: The Value of Adding Mini-oral Pulse Steroid Therapy in Preventing Peri-lesional Halo Post Non-cultured Epidermal Cell Suspension (NCES) in Cases With Stable Segmental and Non-acral Vitiligo: An Interventional Prospective Randomized Controlled Trial.
Status: Opening soon
Description:
The goal of this clinical trial is to learn if adding mini-oral pulse steroid therapy improves the results of non-cultured epidermal cell suspension (NCES) surgery in patients with stable vitiligo. It will also evaluate the safety of this treatment approach. The main questions it aims to answer are: • Does adding mini-oral pulse steroid therapy reduce the development of a perilesional halo after NCES surgery? • Does the addition of steroids improve the degree of repigmentation and overall treatment outcomes in vitiligo lesions? Researchers will compare NCES surgery with mini-oral pulse steroids to NCES surgery alone to determine whether the steroid therapy improves surgical outcomes. Participants will: • Undergo NCES vitiligo surgery for stable segmental or non-acral vitiligo lesions. • Be randomly assigned to receive either surgery alone or surgery plus low-dose oral mini-pulse dexamethasone therapy. • Attend follow-up visits and clinical assessments for approximately 4 months. • Receive excimer laser sessions twice weekly after healing and have standardized photographs and scoring assessments to evaluate repigmentation.
Phase: Phase 4.
What is being studied: procedure — Non-cultured epidermal cell suspension (NCES) surgery; drug — Oral mini pulse; device — Excimer Sessions.
Who can take part: ages 12 Years, 60 participants planned.
Enrollment status: the registry has not updated this study since its planned completion date, so its current status is unclear. The study started 15 March 2026 and was due to finish 01 July 2026.
Source: ClinicalTrials.gov, NCT07472816 (https://clinicaltrials.gov/study/NCT07472816).
Start date: March 15, 2026
Completion date: July 01, 2026
Organizer: Cairo University
Link: https://clinicaltrials.gov/study/NCT07472816
The registry does not list a contact for this study. Use the link above to reach the study record on ClinicalTrials.gov.
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